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Article

Prevalence of genetic alterations in basal cell carcinoma patients resistant to Hedgehog pathway inhibitors: a systematic review.

Annals of medicine - 1 Dec 2025

Untaaveesup Suvijak, Srichana Pornteera, Techataweewan Gynna, Pongphaew Chanamon, Dendumrongsup Wichapol, Ponvilawan Ben, Nampipat Nichanant, Limwongse Chanin

Abstract excerpt

INTRODUCTION: Basal cell carcinoma (BCC) is a prevalent form of skin cancer that can be localized or metastatic. Current evidence supports the use of Hedgehog (Hh) pathway inhibitors for locally advanced or metastatic BCC with resistance due to genetic alterations in the Hh pathway. This systematic review evaluated the prevalence of genetic alterations in Hh pathway genes in BCC. MATERIALS AND METHODS: We...

Read the complete abstract on PubMed

Topics

Humans
Basal Cell Carcinoma
Hedgehog Proteins
Skin Neoplasms
Drug Resistance, Neoplasm
Anilides

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Signal Transduction

Smoothened Receptor

Patched-1 Receptor

Pyridines

Antineoplastic Agents

Prevalence

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 40522768
DOI: 10.1080/07853890.2025.2516701
PMCID: PMC12172076

Genes

PTCH1
SMO
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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