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Article

Genetic Factors Influencing B-type Natriuretic Peptide-Mediated Production of Cyclic Guanosine Monophosphate and Blood Pressure Effects in Heart Failure Patients.

Journal of cardiovascular translational research - 1 Dec 2015

Lanfear David E, Li Jia, Abbas Raza, She Ricoung, Padhukasahasram Badri, Gupta Ramesh C, Langholz David, Tang W H Wilson, Williams L Keoki, Sabbah Hani N, Chow Sheryl L

Abstract excerpt

Natriuretic peptides (NPs) represent a critical pathway in heart failure (HF). We explored genetic determinants of pharmacodynamic effects of B-type NP (BNP) and changes in plasma cyclic guanosine monophosphate (cGMP) and blood pressure (BP). HF patients (n = 135) received recombinant human BNP (nesiritide) at standard doses, and plasma cGMP levels were measured at baseline and during infusion. We tested the...

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Source

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Identifiers

PMID: 26589601
DOI: 10.1007/s12265-015-9660-2
PMCID: PMC4686234

Genes

MME
NPR1
NPR2
NPR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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