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Article

Genetic and nongenetic factors influencing pharmacokinetics of B-type natriuretic peptide.

Journal of cardiac failure - 1 Sept 2014

Lanfear David E, Chow Sheryl, Padhukasahasram Badri, Li Jia, Langholz David, Tang W H Wilson, Williams L Keoki, Sabbah Hani N

Abstract excerpt

BACKGROUND: Natriuretic peptides (NPs) represent a critical pathway in heart failure (HF). However, there is wide individual variability in NP system activity, which could be partly genetic in origin. We explored genetic and nongenetic contributions to B-type natriuretic peptide (BNP) inactivation. METHODS: Chronic HF patients (n = 95) received recombinant human BNP (nesiritide) at standard doses, and BNP levels...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24983826
DOI: 10.1016/j.cardfail.2014.06.357
PMCID: PMC4189182

Genes

MME
NPR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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