A novel agonist antibody to membrane-bound guanylate cyclase receptor, natriuretic peptide receptor 1, induces sustained vasodilation

Abstract excerpt

<title>Abstract</title> <p>Heart failure (HF) is a leading cause of morbidity and mortality. Elevated intracardiac pressures and myocyte stretch in HF triggers release of counter-regulatory natriuretic peptides (NPs), which act via their receptor (NPR1) to affect vasodilation and natriuresis, lowering venous pressures and relieving venous congestion. Recombinant NP infusions were developed to treat HF but have be...

Topics

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• Atrial Natriuretic Factor
• Drug Design
• Genetic Variation
• Heart Failure
• Neprilysin
• Protease Inhibitors
• Protein Engineering
• Proteolysis

Identifiers and source

Literature Corpus work

26090578-c204-5b7d-89af-1e9f01326e18

DOI

10.21203/rs.3.rs-2828284/v1