Article
Association of genetic variation with gene expression and protein abundance within the natriuretic peptide pathway.
Journal of cardiovascular translational research - 1 Oct 2013
Lanfear David E, Sunkara Bipin, Li Jia, Rastogi Sharad, Gupta Ramesh C, Padhukasahasram Badri, Williams L Keoki, Sabbah Hani N
Abstract excerpt
The natriuretic peptide (NP) system is a critical physiologic pathway in heart failure with wide individual variability in functioning. We investigated the genetic component by testing the association of single nucleotide polymorphisms (SNP) with RNA and protein expression. Samples of DNA, RNA, and tissue from human kidney (n = 103) underwent genotyping, RT-PCR, and protein quantitation (in lysates), for four...
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