Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2005

Takahashi Yuri, Miyoshi Yasuo, Takahata Chie, Irahara Natsumi, Taguchi Tetsuya, Tamaki Yasuhiro, Noguchi Shinzaburo

Abstract excerpt

PURPOSE: LATS1 and LATS2 are tumor suppressor genes implicated in the regulation of cell cycle. Methylation status of the promoter regions of these genes as well as its correlation with their mRNA levels were studied in human breast cancers. Correlation of LATS1 and LATS2 mRNA levels with clinicopathologic characteristics of breast tumors were also studied. EXPERIMENTAL DESIGN: Methylation status of promoter...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease-Free Survival
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to Down-Regulation

Share to Gene Expression Regulation, Neoplastic

Share to Lymphatic Metastasis

Share to Protein Serine-Threonine Kinases

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 15746036
DOI: 10.1158/1078-0432.CCR-04-1773

Genes

LATS1
LATS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers.PMID 15746036Read ↗

LATS tumor suppressor: A new governor of cellular homeostasisSemantic proximity Read ↗

WWP1 E3 Ligase Targets LATS1 for Ubiquitin-Mediated Degradation in Breast Cancer CellsSemantic proximity Read ↗

A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1Semantic proximity Read ↗

Identification of LATS transcriptional targets in HeLa cells using whole human genome oligonucleotide microarraySemantic proximity Read ↗

Down-regulation of LATS kinases alters p53 to promote cell migration.Semantic proximity Read ↗

Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma.Semantic proximity Read ↗

MIR22HG inhibits breast cancer progression by stabilizing LATS2 tumor suppressor.Semantic proximity Read ↗

The role of lats in cell cycle regulation and tumorigenesis.Semantic proximity Read ↗

LATS2 tumour specific mutations and down-regulation of the gene in non-small cell carcinoma.Semantic proximity Read ↗

Evidence for a tumor suppressor role for the large tumor suppressor genes LATS1 and LATS2 in human cancer.Semantic proximity Read ↗

Loss of Leucine Zipper Putative Tumor Suppressor 1 (LZTS1) Expression Contributes to Lymph Node Metastasis of Breast Invasive Micropapillary Carcinoma.Semantic proximity Read ↗

Role of DNA methylation in miR-200c/141 cluster silencing in invasive breast cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.