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Article

A Coagulation Factor IX-Deficient Mouse Model for Human Hemophilia B

15 Nov 1997

Abstract excerpt

Coagulation factor IX deficiency causes hemophilia B in humans. We have used gene targeting to develop a coagulation factor IX-deficient (factor IX-knockout) mouse strain. Mouse embryonic stem (ES) cells were targeted by a socket-containing vector that replaces the promoter through exon 3 of the factor IX gene by neoDeltaHPRT, which is a functional neo gene plus a partially deleted hypoxanthine phosphoribosyl...

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Identifiers

PMID: 9354664
DOI: 10.1182/blood.v90.10.3962

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