Article
Novel hemophilia B mouse models exhibiting a range of mutations in the Factor IX gene.
Blood - 1 Nov 2004
Sabatino Denise E, Armstrong Elina, Edmonson Shyrie, Liu Yi-Lin, Pleimes Marc, Schuettrumpf Joerg, Fitzgerald Julie, Herzog Roland W, Arruda Valder R, High Katherine A
Abstract excerpt
Animal models have been critical to the development of novel therapeutics in hemophilia. A deficiency of current murine models of hemophilia B is that they are all due to gene deletions, a type of mutation that is relatively rare in the human hemophilia population. We generated mice with a range...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.