Article
Susceptibility to scrapie and disease phenotype in sheep: cross-PRNP genotype experimental transmissions with natural sources.
Veterinary research - 2 Jul 2012
González Lorenzo, Jeffrey Martin, Dagleish Mark P, Goldmann Wilfred, Sisó Sílvia, Eaton Samantha L, Martin Stuart, Finlayson Jeanie, Stewart Paula, Steele Philip, Pang Yvonne, Hamilton Scott, Reid Hugh W, Chianini Francesca
Abstract excerpt
It has long been established that the sheep Prnp genotype influences the susceptibility to scrapie, and some studies suggest that it can also determine several aspects of the disease phenotype. Other studies, however, indicate that the source of infection may also play a role in such phenotype. To address this question an experiment was set up in which either of two different natural scrapie sources, AAS from...
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