Article
Bioinformatics Analysis to Determine Prognostic Mutations of 72 de novo Acute Myeloid Leukemia Cases from the Cancer Genome Atlas (TCGA) with 23 Most Common Mutations and no Abnormal Cytogenetics.
Annals of clinical and laboratory science - 1 Jan 2015
Welsh Kerry J, Nedelcu Elena, Wahed Amer, Bai Yu, Dasgupta Amitava, Nguyen Andy
Abstract excerpt
OBJECTIVES: Up to 40% of acute myeloid leukemia (AML) patients have normal cytogenetics (CN-AML) but they may have gene mutations. An important issue in the treatment of CN-AML is how gene mutation patterns may help with patient management. The Cancer Genome Atlas (TCGA) database has data from 200 cases of de novo AML including cytogenetics, gene mutations, and survival duration (prognosis). METHODS: Cases with...
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