Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression.

Molecular cell - 17 Feb 2022

Wang Dong, Xu Chenchen, Yang Wenyu, Chen Jie, Ou Yuhui, Guan Yuanyuan, Guan Jialiang, Liu Ying

Abstract excerpt

The mTOR complex 1 (mTORC1) is an essential metabolic hub that coordinates cellular metabolism with the availability of nutrients, including amino acids. Sestrin2 has been identified as a cytosolic leucine sensor that transmits leucine status signals to mTORC1. In this study, we identify an E3 ubiquitin ligase RING finger protein 167 (RNF167) and a deubiquitinase STAMBPL1 that function in concert to control the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caco-2 Cells
Share to HCT116 Cells
Share to Leucine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mechanistic Target of Rapamycin Complex 1

Share to Peptide Hydrolases

Share to TOR Serine-Threonine Kinases

Share to Tumor Burden

Share to Ubiquitination

Source

Identifiers

PMID: 35114100
DOI: 10.1016/j.molcel.2022.01.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression.PMID 35114100Read ↗

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.Semantic proximity Read ↗

Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signallingSemantic proximity Read ↗

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.Semantic proximity Read ↗

RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesisSemantic proximity Read ↗

The CTLH Ubiquitin Ligase Substrates ZMYND19 and MKLN1 Negatively Regulate mTORC1 at the Lysosomal MembraneSemantic proximity Read ↗

mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.Semantic proximity Read ↗

Nucleoporin 210 Serves a Key Scaffold for SMARCB1 in Liver CancerSemantic proximity Read ↗

LAPTM4B counteracts ferroptosis via suppressing the ubiquitin-proteasome degradation of SLC7A11 in non-small cell lung cancerSemantic proximity Read ↗

Disruption of the Keap1-mTORC2 axis by cancer-derived Keap1/mLST8 mutations leads to oncogenic mTORC2-AKT activation.Semantic proximity Read ↗

LARP6 suppresses colorectal cancer progression through ZNF267/SGMS2-mediated imbalance of sphingomyelin synthesisSemantic proximity Read ↗

Bi-allelic KICS2 mutations impair KICSTOR complex-mediated mTORC1 regulation, causing intellectual disability and epilepsy.Semantic proximity Read ↗

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.