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Article

MicroRNA-3151 inactivates TP53 in BRAF-mutated human malignancies.

Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 2015

Lankenau Malori A, Patel Ravi, Liyanarachchi Sandya, Maharry Sophia E, Hoag Kevin W, Duggan Megan, Walker Christopher J, Markowitz Joseph, Carson William E, Eisfeld Ann-Kathrin, de la Chapelle Albert

Abstract excerpt

The B-Raf proto-oncogene serine/threonine kinase (BRAF) gene is the most frequently mutated gene in malignant melanoma (MM) and papillary thyroid cancer (PTC) and is causally involved in malignant cell transformation. Mutated BRAF is associated with an aggressive disease phenotype, thus making it a top candidate for targeted treatment strategies in MM and PTC. We show that BRAF mutations in both MM and PTC drive...

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Identifiers

PMID: 26582795
DOI: 10.1073/pnas.1520390112
PMCID: PMC4679059

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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