Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MicroRNA-215-5p Treatment Suppresses Mesothelioma Progression via the MDM2-p53-Signaling Axis

3 Jun 2019

Abstract excerpt

Malignant pleural mesothelioma (MPM) is an incurable, aggressive neoplasm with distinctive features, including preservation of wild-type p53, irrespective of histologic subtype. We posited that this consistent molecular characteristic represents an underexploited therapeutic target that can be approached by leveraging biologic effects of microRNA (miRNA). The Cancer Genome Atlas was surveyed to identify...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Research and Treatments
Share to Medical Imaging and Pathology Studies
Share to Occupational and environmental lung diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31227395
DOI: 10.1016/j.ymthe.2019.05.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MicroRNA-215-5p Treatment Suppresses Mesothelioma Progression via the MDM2-p53-Signaling AxisPMID 31227395Read ↗

P53-regulated miR-320a targets PDL1 and is downregulated in malignant mesotheliomaSemantic proximity Read ↗

microRNA-497-5p-based screening identifies a novel synthetic lethal-type interaction via PKMYT1 and WEE1 in pleural mesotheliomaSemantic proximity Read ↗

Manipulating microRNAs for the Treatment of Malignant Pleural Mesothelioma: Past, Present and FutureSemantic proximity Read ↗

Overexpression of microRNA‑486 affects the proliferation and chemosensitivity of mesothelioma cell lines by targeting PIM1Semantic proximity Read ↗

Protumorigenic effects of mir-145 loss in malignant pleural mesotheliomaSemantic proximity Read ↗

microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesisSemantic proximity Read ↗

Deciphering signaling pathway interplay via miRNAs in malignant pleural mesotheliomaSemantic proximity Read ↗

Synergistic targeting of malignant pleural mesothelioma cells by MDM2 inhibitors and TRAIL agonists.Semantic proximity Read ↗

MicroRNA-3151 inactivates TP53 in BRAF-mutated human malignancies.Semantic proximity Read ↗

CRISPR Screening Identifies WEE1 as a Combination Target for Standard Chemotherapy in Malignant Pleural MesotheliomaSemantic proximity Read ↗

Downregulated microRNAs in the differential diagnosis of malignant pleural mesotheliomaSemantic proximity Read ↗

A link between the fibroblast growth factor axis and the miR‐16 family reveals potential new treatment combinations in mesotheliomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.