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Article

Intronic miR-3151 within BAALC drives leukemogenesis by deregulating the TP53 pathway.

Science signaling - 15 Apr 2014

Eisfeld Ann-Kathrin, Schwind Sebastian, Patel Ravi, Huang Xiaomeng, Santhanam Ramasamy, Walker Christopher J, Markowitz Joseph, Hoag Kevin W, Jarvinen Tiina M, Leffel Benjamin, Perrotti Danilo, Carson William E, Marcucci Guido, Bloomfield Clara D, de la Chapelle Albert

Abstract excerpt

The BAALC/miR-3151 locus on chromosome 8q22 contains both the BAALC gene (for brain and acute leukemia, cytoplasmic) and miR-3151, which is located in intron 1 of BAALC. Older acute myeloid leukemia (AML) patients with high expression of both miR-3151 and the BAALC mRNA transcript have a low survival prognosis, and miR-3151 and BAALC expression is associated with poor survival independently of each other. We...

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Identifiers

PMID: 24736457
DOI: 10.1126/scisignal.2004762
PMCID: PMC4165404

Genes

BAALC
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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