Article
RNA sequencing identifies multiple fusion transcripts, differentially expressed genes, and reduced expression of immune function genes in BRAF (V600E) mutant vs BRAF wild-type papillary thyroid carcinoma.
The Journal of clinical endocrinology and metabolism - 1 Feb 2014
Smallridge Robert C, Chindris Ana-Maria, Asmann Yan W, Casler John D, Serie Daniel J, Reddi Honey V, Cradic Kendall W, Rivera Michael, Grebe Stefan K, Necela Brian M, Eberhardt Norman L, Carr Jennifer M, McIver Bryan, Copland John A, Thompson E Aubrey
Abstract excerpt
CONTEXT: The BRAF V600E mutation (BRAF-MUT) confers an aggressive phenotype in papillary thyroid carcinoma, but unidentified additional genomic abnormalities may be required for full phenotypic expression. OBJECTIVE: RNA sequencing (RNA-Seq) was performed to identify genes differentially expressed between BRAF-MUT and BRAF wild-type (BRAF-WT) tumors and to correlate changes to patient clinical status. DESIGN:...
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