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PARP1 negatively regulates MAPK signaling by impairing BRAF-X1 translation

3 Apr 2023

Abstract excerpt

In human cells BRAF oncogene is invariably expressed as a mix of two coding transcripts: BRAF-ref and BRAF-X1. These two mRNA isoforms, remarkably different in the sequence and length of their 3'UTRs, are potentially involved in distinct post-transcriptional regulatory circuits. Herein, we identify PARP1 among the mRNA Binding Proteins that specifically target the X1 3'UTR in melanoma cells. Mechanistically,...

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PMID: 37013641
DOI: 10.1186/s13045-023-01428-2

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