Article
TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.
Blood - 21 Jun 2018
Jethwa Alexander, Słabicki Mikołaj, Hüllein Jennifer, Jentzsch Marius, Dalal Vineet, Rabe Sophie, Wagner Lena, Walther Tatjana, Klapper Wolfram, Bohnenberger Hanibal, Rettel Mandy, Lu Junyan, Smits Arne H, Stein Frank, Savitski Mikhail M, Huber Wolfgang, Aylon Yael, Oren Moshe, Zenz Thorsten
Abstract excerpt
Tumors accumulate high levels of mutant p53 (mutp53), which contributes to mutp53 gain-of-function properties. The mechanisms that underlie such excessive accumulation are not fully understood. To discover regulators of mutp53 protein accumulation, we performed a large-scale RNA interference screen in a Burkitt lymphoma cell line model. We identified transformation/transcription domain-associated protein (TRRAP),...
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