Article
Divergent signaling via SUMO modification: potential for CFTR modulation.
American journal of physiology. Cell physiology - 1 Feb 2016
Ahner Annette, Gong Xiaoyan, Frizzell Raymond A
Abstract excerpt
The cystic fibrosis transmembrane conductance regulator (CFTR) is generally responsible for the cAMP/PKA regulated anion conductance at the apical membranes of secretory epithelial cells. Mutations in CFTR underlie cystic fibrosis (CF), in which the most common variant, F508del, causes protein misfolding and its proteasome-mediated degradation. A new pathway that contributes to mutant CFTR degradation is mediated...
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