Article
Sumoylation silences the plasma membrane leak K+ channel K2P1.
Cell - 8 Apr 2005
Rajan Sindhu, Plant Leigh D, Rabin Michael L, Butler Margaret H, Goldstein Steve A N
Abstract excerpt
Reversible, covalent modification with small ubiquitin-related modifier proteins (SUMOs) is known to mediate nuclear import/export and activity of transcription factors. Here, the SUMO pathway is shown to operate at the plasma membrane to control ion channel function. SUMO-conjugating enzyme is seen to be resident in plasma membrane, to assemble with K2P1, and to modify K2P1 lysine 274. K2P1 had not previously...
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