Article

Degradation of CFTR-F508del By the Ubiquitin E2 Conjugating Enzyme UBE 2L6 and the E3 Ligase RNF19B

2019-07-17

Abstract excerpt

<title>Abstract</title> <p>Background Cystic Fibrosis (CF) is the most common, lethal autosomal-recessive disorder, and is caused by mutations in the cystic fibrosis transmembrane conductance regulator protein (CFTR), an anion channel that is found in epithelial cells lining multiple organs. The most common mutation of CFTR is deletion of phenylalanine at position 508 (CFTR-F508del), which produces a misfolded p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fc97c508-1f85-5e19-8d84-980d0565bf70
DOI: 10.21203/rs.2.11477/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Degradation of CFTR-F508del By the Ubiquitin E2 Conjugating Enzyme UBE 2L6 and the E3 Ligase RNF19BDOI 10.21203/rs.2.11477/v1Read

Small molecule correctors divert CFTR-F508del from ERAD by stabilizing sequential folding statesSemantic proximity Read

Cystic fibrosis transmembrane conductance regulator degradation: cross-talk between the ubiquitylation and SUMOylation pathways.Semantic proximity Read

Targeting ubiquitination machinery in cystic fibrosis: Where do we stand?Semantic proximity Read

Small-molecule correctors divert CFTR-F508del from ERAD by stabilizing sequential folding states.Semantic proximity Read

KDM2A and KDM3B as Potential Targets for the Rescue of F508del-CFTR.Semantic proximity Read

Biosynthesis and degradation of CFTR.Semantic proximity Read

High-throughput screening identifies FAU protein as a regulator of mutant cystic fibrosis transmembrane conductance regulator channel.Semantic proximity Read

SYVN1, NEDD8, and FBXO2 Proteins Regulate ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitin-mediated Proteasomal DegradationSemantic proximity Read

Derlin-1 promotes the efficient degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR folding mutants.Semantic proximity Read

The multiple ubiquitination mechanisms in CFTR peripheral quality control.Semantic proximity Read

Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation.Semantic proximity Read

Ubiquitin C-terminal hydrolase-L1 protects cystic fibrosis transmembrane conductance regulator from early stages of proteasomal degradation.Semantic proximity Read