Article
Silencing of the Hsp70-specific nucleotide-exchange factor BAG3 corrects the F508del-CFTR variant by restoring autophagy.
The Journal of biological chemistry - 31 Aug 2018
Hutt Darren M, Mishra Sanjay Kumar, Roth Daniela Martino, Larsen Mads Breum, Angles Frédéric, Frizzell Raymond A, Balch William E
Abstract excerpt
The protein chaperones heat shock protein 70 (Hsp70) and Hsp90 are required for de novo folding of proteins and protect against misfolding-related cellular stresses by directing misfolded or slowly folding proteins to the ubiquitin/proteasome system (UPS) or autophagy/lysosomal degradation pathways. Here, we examined the role of the Bcl2-associated athanogene (BAG) family of Hsp70-specific nucleotide-exchange...
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