Article
SUMOylation Inhibition Enhances Protein Transcription under CMV Promoter: A Lesson from a Study with the F508del-CFTR Mutant.
International journal of molecular sciences - 15 Feb 2024
Borgo Christian, D'Amore Claudio, Capurro Valeria, Tomati Valeria, Pedemonte Nicoletta, Bosello Travain Valentina, Salvi Mauro
Abstract excerpt
Cystic fibrosis (CF) is a genetic disorder caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), a selective anion channel expressed in the epithelium of various organs. The most frequent mutation is F508del. This mutation leads to a misfolded CFTR protein quickly degraded via ubiquitination in the endoplasmic reticulum. Although preventing ubiquitination...
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