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Article

Comparison of the clinical prediction model PREMM 1,2,6 and molecular testing for the systematic identification of Lynch syndrome in colorectal cancer

16 Feb 2012

Abstract excerpt

BACKGROUND: Lynch syndrome is caused by germline mismatch repair (MMR) gene mutations. The PREMM(1,2,6) model predicts the likelihood of a MMR gene mutation based on personal and family cancer history. OBJECTIVE: To compare strategies using PREMM(1,2,6) and tumour testing (microsatellite instability (MSI) and/or immunohistochemistry (IHC) staining) to identify mutation carriers. DESIGN: Data from population-based...

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PMID: 22345660
DOI: 10.1136/gutjnl-2011-301265

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