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Article

Predictive models for mutations in mismatch repair genes: implication for genetic counseling in developing countries.

BMC cancer - 9 Feb 2012

Monteiro Santos Erika Maria, Valentin Mev Dominguez, Carneiro Felipe, de Oliveira Ligia Petrolini, de Oliveira Ferreira Fabio, Junior Samuel Aguiar, Nakagawa Wilson Toshihiko, Gomy Israel, de Faria Ferraz Victor Evangelista, da Silva Junior Wilson Araujo, Carraro Dirce Maria, Rossi Benedito Mauro

Abstract excerpt

BACKGROUND: Lynch syndrome (LS) is the most common form of inherited predisposition to colorectal cancer (CRC), accounting for 2-5% of all CRC. LS is an autosomal dominant disease characterized by mutations in the mismatch repair genes mutL homolog 1 (MLH1), mutS homolog 2 (MSH2), postmeiotic segregation increased 1 (PMS1), post-meiotic segregation increased 2 (PMS2) and mutS homolog 6 (MSH6). Mutation risk...

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Source

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Identifiers

PMID: 22321913
DOI: 10.1186/1471-2407-12-64
PMCID: PMC3305354

Genes

MLH1
MSH2
MSH6
PMS1
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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