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Article

The PREMM(1,2,6) model predicts risk of MLH1, MSH2, and MSH6 germline mutations based on cancer history.

Gastroenterology - 1 Jan 2011

Kastrinos Fay, Steyerberg Ewout W, Mercado Rowena, Balmaña Judith, Holter Spring, Gallinger Steven, Siegmund Kimberly D, Church James M, Jenkins Mark A, Lindor Noralane M, Thibodeau Stephen N, Burbidge Lynn Anne, Wenstrup Richard J, Syngal Sapna

Abstract excerpt

BACKGROUND & AIMS: We developed and validated a model to estimate the risks of mutations in the mismatch repair (MMR) genes MLH1, MSH2, and MSH6 based on personal and family history of cancer. METHODS: Data were analyzed from 4539 probands tested for mutations in MLH1, MSH2, and MSH6. A multivari...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20727894
DOI: 10.1053/j.gastro.2010.08.021
PMCID: PMC3125673

Genes

MLH1
MSH2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20727894-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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