Article
Evaluation of predictive models in daily practice for the identification of patients with Lynch syndrome.
International journal of cancer - 15 Mar 2012
Tresallet Christophe, Brouquet Antoine, Julié Catherine, Beauchet Alain, Vallot Céline, Ménégaux Fabrice, Mitry Emmanuel, Radvanyi François, Malafosse Robert, Rougier Philippe, Nordlinger Bernard, Laurent-Puig Pierre, Boileau Catherine, Emile Jean-François, Muti Christine, Penna Christophe, Hofmann-Radvanyi Hélène
Abstract excerpt
The optimal strategy for identifying patients with Lynch syndrome among patients with newly diagnosed colorectal cancer (CRC) is still debated. Several predictive models (e.g., MMRpredict, PREMM1,2 and MMRpro) combining personal and familial data have recently been developed to quantify the risk that a given patient with CRC carries a Lynch syndrome-causing mutation. Their clinical applicability to patients with...
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