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Article

Performance of Lynch Syndrome Predictive Models in a Multi-Center US Referral Population

12 Jul 2011

Abstract excerpt

OBJECTIVES: Lynch syndrome is the most common cause of inherited colorectal cancer (CRC) and is due to germline mutations in mismatch repair (MMR) genes. Early Lynch syndrome diagnosis and appropriate CRC surveillance improves mortality. Traditional qualitative clinical criteria including Amsterdam and Bethesda guidelines may miss mutation carriers. Recently, quantitative predictive models including MMRPredict,...

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PMID: 21747416
DOI: 10.1038/ajg.2011.200

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