Article
Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotype.
Blood - 1 Aug 1997
Koene H R, Kleijer M, Algra J, Roos D, von dem Borne A E, de Haas M
Abstract excerpt
We analyzed a genetic polymorphism of Fc gamma receptor IIIa (CD16) that is present on position 158 (Phe or Val) in the membrane-proximal, IgG-binding domain. With a polymerase chain reaction-based allele-specific restriction analysis assay we genotyped 87 donors and found gene frequencies of 0.57 and 0.43 for Fc gammaRIIIA-158F and -158V, respectively. A clear linkage was observed between the Fc gammaRIIIA-158F...
Topics
- Alleles
- Antibodies, Monoclonal
- Genotype
- Humans
- Immunoglobulin G
- Killer Cells, Natural
- Phenotype
- Polymorphism, Genetic
- Protein Binding
- Receptors, IgG