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A Molecular Mechanism for Eflornithine Resistance in African Trypanosomes

24 Nov 2010

Abstract excerpt

Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the protozoan parasite Trypanosoma brucei. Eflornithine is used as a first line treatment for human African trypanosomiasis, but there is a risk that resistance could thwart its use, even when used in combination therapy with nifurtimox. Eflornithine resistant trypanosomes were selected in vitro...

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PMID: 21124824
DOI: 10.1371/journal.ppat.1001204

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