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Myeloma and DNA damage

22 Nov 2023

Abstract excerpt

ABSTRACT: DNA-damaging agents have represented the first effective treatment for the blood cancer multiple myeloma, and after 65 years since their introduction to the clinic, they remain one of the mainstay therapies for this disease. Myeloma is a cancer of plasma cells. Despite exceedingly slow proliferation, myeloma cells present extended genomic rearrangements and intense genomic instability, starting at the...

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PMID: 37992215
DOI: 10.1182/blood.2023021384

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