Article
The USP8 mutational status may predict drug susceptibility in corticotroph adenomas of Cushing's disease.
European journal of endocrinology - 1 Feb 2016
Hayashi Kyohei, Inoshita Naoko, Kawaguchi Kohei, Ibrahim Ardisasmita Arif, Suzuki Hisanori, Fukuhara Noriaki, Okada Mitsuo, Nishioka Hiroshi, Takeuchi Yasuhiro, Komada Masayuki, Takeshita Akira, Yamada Shozo
Abstract excerpt
CONTEXT: Somatic mutations in the ubiquitin-specific peptidase USP8 gene were recently detected in one- to two-third(s) of corticotroph adenomas of Cushing's disease (CD). These mutations may lead to the deubiquitination of EGFR, thereby increasing EGFR signaling, which has been implicated in ACTH hypersecretion. OBJECTIVE: Our objective was to determine the impact of USP8 mutations on the clinicopathological...
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