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Article

Structural basis for RNA-genome recognition during bacteriophage Qβ replication.

Nucleic acids research - 15 Dec 2015

Gytz Heidi, Mohr Durita, Seweryn Paulina, Yoshimura Yuichi, Kutlubaeva Zarina, Dolman Fleur, Chelchessa Bosene, Chetverin Alexander B, Mulder Frans A A, Brodersen Ditlev E, Knudsen Charlotte R

Abstract excerpt

Upon infection of Escherichia coli by bacteriophage Qβ, the virus-encoded β-subunit recruits host translation elongation factors EF-Tu and EF-Ts and ribosomal protein S1 to form the Qβ replicase holoenzyme complex, which is responsible for amplifying the Qβ (+)-RNA genome. Here, we use X-ray crystallography, NMR spectroscopy, as well as sequence conservation, surface electrostatic potential and mutational...

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Identifiers

PMID: 26578560
DOI: 10.1093/nar/gkv1212
PMCID: PMC4678825

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Source receipt: pubmed, retrieved 7 Sept 2026.

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