Article
Altered 3'-terminal RNA structure in phage Qbeta adapted to host factor-less Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 1997
Schuppli D, Miranda G, Tsui H C, Winkler M E, Sogo J M, Weber H
Abstract excerpt
The RNA phage Qbeta requires for the replication of its genome an RNA binding protein called Qbeta host factor or Hfq protein. Our previous results suggested that this protein mediates the access of replicase to the 3'-end of the Qbeta plus strand RNA. Here we report the results of an evolutionary experiment in which phage Qbeta was adapted to an Escherichia coli Q13 host strain with an inactivated host factor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.