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Article

Modulation of Macrophage Functional Polarity towards Anti-Inflammatory Phenotype with Plasmid DNA Delivery in CD44 Targeting Hyaluronic Acid Nanoparticles.

Scientific reports - 18 Nov 2015

Tran Thanh-Huyen, Rastogi Ruchir, Shelke Juili, Amiji Mansoor M

Abstract excerpt

The purpose of this study was to modulate macrophage polarity from the pro-inflammatory M1 to anti-inflammatory M2 phenotype using plasmid DNA (pDNA) expressing interleukin-4 (IL4) or interleukin-10 (IL10)-encapsulated in hyaluronic acid-poly(ethyleneimine) (HA-PEI) nanoparticles (NPs). The HA-PEI/pDNA NPs with spherical shape, average size of 186 nm were efficiently internalized by J774A.1 macrophages....

Topics

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Hyaluronan Receptors
Hyaluronic Acid
Inflammation Mediators
Interleukin-10
Interleukin-4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macrophages, Peritoneal

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Open in PubMed Open full text

Identifiers

PMID: 26577684
DOI: 10.1038/srep16632
PMCID: PMC4649614

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TNF

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