Article

AI-Driven Comparative Genomics for Human Regenerative Gene Discovery Using Axolotl as a Model

2026-04-07

Abstract excerpt

<title>Abstract</title> <p>Humans typically repair injuries through incomplete structural restoration and fibrosis, whereas axolotls can regenerate complex appendages. Whether this difference reflects loss of key regeneration genes or incomplete deployment of conserved programs remains unresolved. Here, we integrated public axolotl limb regeneration RNA-seq data with cross-species mapping and supervised machine l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 68f03a08-d9fe-57a2-9ab3-507c54b13a82
DOI: 10.21203/rs.3.rs-9321844/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

AI-Driven Comparative Genomics for Human Regenerative Gene Discovery Using Axolotl as a ModelDOI 10.21203/rs.3.rs-9321844/v1Read

Comparative RNA-seq Analysis in the Unsequenced Axolotl: The Oncogene Burst Highlights Early Gene Expression in the BlastemaSemantic proximity Read

Key Proteins for Regeneration in <i>A. mexicanum</i> : Transcriptomic Insights from Aged and Juvenile LimbsSemantic proximity Read

Single-Cell RNA-Seq Reveals Novel Mitochondria-related Musculoskeletal Cell Populations during Adult Axolotl Limb Regeneration ProcessSemantic proximity Read

Overview of the expression of key regeneration genes in embryo development and matured tissues in Axolotl ( <i>Ambystoma mexicanum</i> )Semantic proximity Read

Multi-species atlas resolves an axolotl limb development and regeneration paradoxSemantic proximity Read

Limbform: a functional ontology-based database of limb regeneration experiments.Semantic proximity Read

Identification of regenerative roadblocks via repeat deployment of limb regeneration in axolotlsSemantic proximity Read

Axolotl regeneration reveals a dormant cis-regulatory grammar conserved across vertebrate genomesSemantic proximity Read

Functional rescue of critical-size bone defect using molecular network analysis of axolotl limb regenerationSemantic proximity Read

Identification of rare transient somatic cell states induced by injury and required for whole-body regenerationSemantic proximity Read

Limb Regeneration in Axolotl: Is It Superhealing?Semantic proximity Read

A Workflow for Spatial Transcriptomic Analysis from Intra-operative Human Skeletal Muscle BiopsiesSemantic proximity Read