Article
The epigenetic modifier Fam208a is required to maintain epiblast cell fitness.
Scientific reports - 24 Aug 2017
Bhargava Shohag, Cox Brian, Polydorou Christiana, Gresakova Veronika, Korinek Vladimir, Strnad Hynek, Sedlacek Radislav, Epp Trevor Allan, Chawengsaksophak Kallayanee
Abstract excerpt
Gastrulation initiates with the formation of the primitive streak, during which, cells of the epiblast delaminate to form the mesoderm and definitive endoderm. At this stage, the pluripotent cell population of the epiblast undergoes very rapid proliferation and extensive epigenetic programming. Here we show that Fam208a, a new epigenetic modifier, is essential for early post-implantation development. We show that...
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