Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor suppressors: enhancers or suppressors of regeneration?

Development (Cambridge, England) - 1 Jun 2013

Pomerantz Jason H, Blau Helen M

Abstract excerpt

Tumor suppressors are so named because cancers occur in their absence, but these genes also have important functions in development, metabolism and tissue homeostasis. Here, we discuss known and potential functions of tumor suppressor genes during tissue regeneration, focusing on the evolutionarily conserved tumor suppressors pRb1, p53, Pten and Hippo. We propose that their activity is essential for tissue...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase Inhibitor p16
Share to Disease Susceptibility
Share to Drosophila

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Genes, Tumor Suppressor

Share to Intracellular Signaling Peptides and Proteins

Share to PTEN Phosphohydrolase

Share to Regeneration

Source

Open in PubMed Open full text

Identifiers

PMID: 23715544
DOI: 10.1242/dev.084210
PMCID: PMC3666379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor suppressors: enhancers or suppressors of regeneration?PMID 23715544Read ↗

p53 on the crossroad between regeneration and cancerSemantic proximity Read ↗

Tumor Suppressors Having Oncogenic Functions: The Double Agents.Semantic proximity Read ↗

Principles of tumor suppression.Semantic proximity Read ↗

The retinoblastoma tumor suppressor and stem cell biology.Semantic proximity Read ↗

Twists in views on RB functions in cellular signaling, metabolism and stem cells.Semantic proximity Read ↗

Suppression of the SWI/SNF Component Arid1a Promotes Mammalian RegenerationSemantic proximity Read ↗

The Retinoblastoma pathway regulates stem cell proliferation in freshwater planarians.Semantic proximity Read ↗

Functional Mechanisms for Human Tumor SuppressorsSemantic proximity Read ↗

Cellular mechanisms of tumour suppression by the retinoblastoma gene.Semantic proximity Read ↗

A hypothetical anti-neoplastic mechanism associated to reserve cells.Semantic proximity Read ↗

The human ARF tumor suppressor senses blastema activity and suppresses epimorphic tissue regenerationSemantic proximity Read ↗

<scp>PTEN</scp> controls β‐cell regeneration in aged mice by regulating cell cycle inhibitor p16 <sup> <i>ink4a</i> </sup>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.