Article
C. elegans and mutants with chronic nicotine exposure as a novel model of cancer phenotype.
Cancer biology & therapy - 1 Jan 2016
Kanteti Rajani, Dhanasingh Immanuel, El-Hashani Essam, Riehm Jacob J, Stricker Thomas, Nagy Stanislav, Zaborin Alexander, Zaborina Olga, Biron David, Alverdy John C, Im Hae Kyung, Siddiqui Shahid, Padilla Pamela A, Salgia Ravi
Abstract excerpt
We previously investigated MET and its oncogenic mutants relevant to lung cancer in C. elegans. The inactive orthlogues of the receptor tyrosine kinase Eph and MET, namely vab-1 and RB2088 respectively, the temperature sensitive constitutively active form of KRAS, SD551 (let-60; GA89) and the inactive c-CBL equivalent mutants in sli-1 (PS2728, PS1258, and MT13032) when subjected to chronic exposure of nicotine...
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