Article
A C. elegans model of nicotine-dependent behavior: regulation by TRP-family channels.
Cell - 3 Nov 2006
Feng Zhaoyang, Li Wei, Ward Alex, Piggott Beverly J, Larkspur Erin R, Sternberg Paul W, Xu X Z Shawn
Abstract excerpt
Nicotine, the primary addictive substance in tobacco, induces profound behavioral responses in mammals, but the underlying genetic mechanisms are not well understood. Here we develop a C. elegans model of nicotine-dependent behavior. We show that worms exhibit behavioral responses to nicotine tha...
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