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Article

A C. elegans model of nicotine-dependent behavior: regulation by TRP-family channels.

Cell - 3 Nov 2006

Feng Zhaoyang, Li Wei, Ward Alex, Piggott Beverly J, Larkspur Erin R, Sternberg Paul W, Xu X Z Shawn

Abstract excerpt

Nicotine, the primary addictive substance in tobacco, induces profound behavioral responses in mammals, but the underlying genetic mechanisms are not well understood. Here we develop a C. elegans model of nicotine-dependent behavior. We show that worms exhibit behavioral responses to nicotine that parallel those observed in mammals, including acute response, tolerance, withdrawal, and sensitization. These...

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Identifiers

PMID: 17081982
DOI: 10.1016/j.cell.2006.09.035
PMCID: PMC2859215

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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