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Article

Mutationally activated Rho GTPases in cancer.

Small GTPases - 1 Jan 2000

Alan Jamie K, Lundquist Erik A

Abstract excerpt

The Rho family of GTPases (members of the Ras superfamily) are best known for their roles in regulating cytoskeletal dynamics. It is also well established that misregulation of Rho proteins contributes to tumorigenesis and metastasis. Unlike Ras proteins, which are frequently mutated in cancer (around 30%), Rho proteins themselves are generally not found to be mutated in cancer. Rather, misregulation of Rho...

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PMID: 24088985
DOI: 10.4161/sgtp.26530
PMCID: PMC3976972

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