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An Amphipathic Undecapeptide with All d-Amino Acids Shows Promising Activity against Colistin-Resistant Strains of Acinetobacter baumannii and a Dual Mode of Action.

Antimicrobial agents and chemotherapy - 1 Jan 2016

Oddo Alberto, Thomsen Thomas T, Kjelstrup Susanne, Gorey Ciara, Franzyk Henrik, Frimodt-Møller Niels, Løbner-Olesen Anders, Hansen Paul R

Abstract excerpt

Multiple strains of Acinetobacter baumannii have developed multidrug resistance (MDR), leaving colistin as the only effective treatment. The cecropin-α-melittin hybrid BP100 (KKLFKKILKYL-NH2) and its analogs have previously shown activity against a wide array of plant and human pathogens. In this study, we investigated the in vitro antibacterial activities of 18 BP100 analogs (four known and 14 new) against the...

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Identifiers

PMID: 26574005
DOI: 10.1128/AAC.01966-15
PMCID: PMC4704207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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