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Article

Antibacterial properties of an oligo-acyl-lysyl hexamer targeting Gram-negative species.

Antimicrobial agents and chemotherapy - 1 Sept 2012

Zaknoon Fadia, Goldberg Keren, Sarig Hadar, Epand Raquel F, Epand Richard M, Mor Amram

Abstract excerpt

Toward developing new tools for fighting resistance to antibiotics, we investigated the antibacterial properties of a new decanoyl-based oligo-acyl-lysyl (OAK) hexamer, aminododecanoyl-lysyl-[aminodecanoyl-lysyl](5) (α(12)-5α(10)). The OAK exhibited preferential activity against Gram-negative bacteria (GNB), as determined using 36 strains, including diverse species, with an MIC(90) of 6.2 μM. The OAK's...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22751534
DOI: 10.1128/AAC.00511-12
PMCID: PMC3421859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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