Activity of Cecropin A-Melittin Hybrid Peptides against Colistin-Resistant Clinical Strains of <i>Acinetobacter baumannii</i> : Molecular Basis for the Differential Mechanisms of Action

Abstract excerpt

Acinetobacter baumannii has successfully developed resistance against all common antibiotics, including colistin (polymyxin E), the last universally active drug against this pathogen. The possible widespread distribution of colistin-resistant A. baumannii strains may create an alarming clinical situation. In a previous work, we reported differences in lethal mechanisms between polymyxin B (PXB) and the cecropin...

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