Article
Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production.
Antimicrobial agents and chemotherapy - 1 Dec 2010
Moffatt Jennifer H, Harper Marina, Harrison Paul, Hale John D F, Vinogradov Evgeny, Seemann Torsten, Henry Rebekah, Crane Bethany, St Michael Frank, Cox Andrew D, Adler Ben, Nation Roger L, Li Jian, Boyce John D
Abstract excerpt
Infections caused by multidrug-resistant (MDR) Gram-negative bacteria represent a major global health problem. Polymyxin antibiotics such as colistin have resurfaced as effective last-resort antimicrobials for use against MDR Gram-negative pathogens, including Acinetobacter baumannii. Here we show that A. baumannii can rapidly develop resistance to polymyxin antibiotics by complete loss of the initial binding...
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