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Article

Essential Role of GATA2 in the Negative Regulation of Type 2 Deiodinase Gene by Liganded Thyroid Hormone Receptor β2 in Thyrotroph

16 Nov 2015

Abstract excerpt

The inhibition of thyrotropin (thyroid stimulating hormone; TSH) by thyroid hormone (T3) and its receptor (TR) is the central mechanism of the hypothalamus-pituitary-thyroid axis. Two transcription factors, GATA2 and Pit-1, determine thyrotroph differentiation and maintain the expression of the β subunit of TSH (TSHβ). We previously reported that T3-dependent repression of the TSHβ gene is mediated by GATA2 but...

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PMID: 26571013
DOI: 10.1371/journal.pone.0142400

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Essential Role of GATA2 in the Negative Regulation of Type 2 Deiodinase Gene by Liganded Thyroid Hormone Receptor β2 in ThyrotrophPMID 26571013Read ↗

GATA2 mediates thyrotropin-releasing hormone-induced transcriptional activation of the thyrotropin β gene.Semantic proximity Read ↗

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