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Article

Mediator subunit MED1 is a T3-dependent and T3-independent coactivator on the thyrotropin β gene promoter.

Biochemical and biophysical research communications - 11 Oct 2013

Matsui Keiji, Oda Kasumi, Mizuta Shumpei, Ishino Ruri, Urahama Norinaga, Hasegawa Natsumi, Roeder Robert G, Ito Mitsuhiro

Abstract excerpt

The MED1 subunit of the Mediator transcriptional coregulator complex is a nuclear receptor-specific coactivator. A negative feedback mechanism of thyroid-stimulating hormone (TSH, or thyrotropin) expression in the thyrotroph in the presence of triiodothyronine (T3) is employed by liganded thyroid hormone receptor β (TRβ) on the TSHβ gene promoter, where conventional histone-modifying coactivators act as...

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Source

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Identifiers

PMID: 24055033
DOI: 10.1016/j.bbrc.2013.09.061
PMCID: PMC4388257

Genes

MED1
GATA2
HDAC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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