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Article

GATA2 mediates thyrotropin-releasing hormone-induced transcriptional activation of the thyrotropin β gene.

PloS one - 14 Apr 2011

Ohba Kenji, Sasaki Shigekazu, Matsushita Akio, Iwaki Hiroyuki, Matsunaga Hideyuki, Suzuki Shingo, Ishizuka Keiko, Misawa Hiroko, Oki Yutaka, Nakamura Hirotoshi

Abstract excerpt

Thyrotropin-releasing hormone (TRH) activates not only the secretion of thyrotropin (TSH) but also the transcription of TSHβ and α-glycoprotein (αGSU) subunit genes. TSHβ expression is maintained by two transcription factors, Pit1 and GATA2, and is negatively regulated by thyroid hormone (T3). Our prior studies suggest that the main activator of the TSHβ gene is GATA2, not Pit1 or unliganded T3 receptor (TR). In...

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Identifiers

PMID: 21533184
DOI: 10.1371/journal.pone.0018667
PMCID: PMC3077393

Genes

TRH
GATA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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GATA2 mediates thyrotropin-releasing hormone-induced transcriptional activation of the thyrotropin β gene.PMID 21533184Read ↗

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