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Article

The structural basis of yeast prion strain variants.

Nature - 13 Sept 2007

Toyama Brandon H, Kelly Mark J S, Gross John D, Weissman Jonathan S

Abstract excerpt

Among the many surprises to arise from studies of prion biology, perhaps the most unexpected is the strain phenomenon whereby a single protein can misfold into structurally distinct, infectious states that cause distinguishable phenotypes. Similarly, proteins can adopt a spectrum of conformations in non-infectious diseases of protein folding; some are toxic and others are well tolerated. However, our...

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PMID: 17767153
DOI: 10.1038/nature06108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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