Article

Structural and molecular basis of cross-seeding barriers in amyloids

2020-07-06

Abstract excerpt

Neurodegenerative disorders are frequently associated with β-sheet-rich amyloid deposits. Amyloid-forming proteins can aggregate under different structural conformations known as strains, which can exhibit a prion-like behaviour and distinct patho-phenotypes. Precise molecular determinants defining strain specificity and cross-strain interactions (cross-seeding) are currently unknown. The HET-s prion protein from...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 364314ca-d868-554d-a166-5664ed1965e4
DOI: 10.1101/2020.07.06.188508

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural and molecular basis of cross-seeding barriers in amyloidsDOI 10.1101/2020.07.06.188508Read

Structural Similarity between the Prion Domain of HET-s and a Homologue Can Explain Amyloid Cross-Seeding in Spite of Limited Sequence IdentitySemantic proximity Read

Emerging Principles of Conformation-Based Prion InheritanceSemantic proximity Read

Prion recognition elements govern nucleation, strain specificity and species barriers.Semantic proximity Read

Structural insights into a yeast prion illuminate nucleation and strain diversity.Semantic proximity Read

Heterogeneous seeding of HET-s(218-289) and the mutability of prion structures.Semantic proximity Read

Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+].Semantic proximity Read

The [Het-s] prion of Podospora anserina and its role in heterokaryon incompatibility.Semantic proximity Read

Emergence and evolution of yeast prion and prion-like proteinsSemantic proximity Read

Site-specific structural analysis of a yeast prion strain with species-specific seeding activity.Semantic proximity Read

Exploiting amyloid: how and why bacteria use cross-β fibrilsSemantic proximity Read

Fungal prions.Semantic proximity Read

Prions, protein homeostasis, and phenotypic diversity.Semantic proximity Read