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Article

Structural definition is important for the propagation of the yeast [PSI+] prion.

Molecular cell - 6 Jun 2013

Marchante Ricardo, Rowe Michelle, Zenthon Jo, Howard Mark J, Tuite Mick F

Abstract excerpt

Prions are propagated in Saccharomyces cerevisiae with remarkable efficiency, yet we know little about the structural basis of sequence variations in the prion protein that support or prohibit propagation of the prion conformation. We show that certain single-amino-acid substitutions in the prion protein Sup35 impact negatively on the maintenance of the associated prion-based [PSI(+)] trait by combining in vivo...

Topics

Amino Acid Sequence
Amino Acid Substitution
Conserved Sequence
Electrophoresis, Polyacrylamide Gel
Mutation
Nuclear Magnetic Resonance, Biomolecular
Peptide Termination Factors
Phenotype
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 23746351
DOI: 10.1016/j.molcel.2013.05.010
PMCID: PMC3679450

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